Shopping Cart

Your shopping cart is currently empty

Notoginsenoside R1

Name: Notoginsenoside R1
Brand: TargetMol
SKU: T2961
Price: 37 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T2961Cas No. 80418-24-2

Alias Sanqi glucoside R1, Sanchinoside R1

Notoginsenoside R1 (Sanchinoside R1) has been shown to exhibit antioxidant, antiapoptotic, anti-inflammatory, and immune-stimulatory properties.

Notoginsenoside R1

🥰Excellent

Purity: 99.91%

Catalog No. T2961Alias Sanqi glucoside R1, Sanchinoside R1Cas No. 80418-24-2

Notoginsenoside R1 (Sanchinoside R1) has been shown to exhibit antioxidant, antiapoptotic, anti-inflammatory, and immune-stimulatory properties.

Pack Size	Price	USA Warehouse	Global Warehouse
10 mg	$37	In Stock	In Stock
25 mg	$68	In Stock	In Stock
50 mg	$98	In Stock	In Stock
100 mg	$156	In Stock	In Stock
200 mg	$243	In Stock	In Stock
500 mg	$425	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$38	In Stock	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:99.91%

Color:White

Resource Download

COA LCMS HNMR

Product Introduction

Bioactivity

Description	Notoginsenoside R1 (Sanchinoside R1) has been shown to exhibit antioxidant, antiapoptotic, anti-inflammatory, and immune-stimulatory properties.
In vitro	METHODS: Human colorectal cancer cells HCT-116 were treated with Notoginsenoside R1 (75-300 µM) for 48 h. Cell viability was measured by MTT assay. RESULTS: Cell viability of HCT-116 cells treated with 75-300 µM Notoginsenoside R1 was not significantly different from that of the control. However, treatment with 500 µM Notoginsenoside R1 for 48 h resulted in a significant decrease in cell viability (58±7.26%) compared to control cells. [1] METHODS: Human coronary artery smooth muscle cells hCASMC were treated with Notoginsenoside R1 (10 µM) for 24 h. The cells were stimulated with 10% FBS for 0-30 min, and the expression levels of target proteins were detected by Western Blot. RESULTS: Akt phosphorylation in hCASMCs was rapidly reduced in a time- and dose-dependent manner after Notoginsenoside R1 treatment, but no effect on ERK1/2 and JNK signaling was observed. notoginsenoside R1 caused a modest reduction in p38 MAPK phosphorylation, but this did not reach significance. [2]
In vivo	METHODS: To study the effect on neoplastic endothelial hyperplasia, Notoginsenoside R1 (10 mg/kg) was administered intraperitoneally to C57BL/6 J mice once daily for three weeks. A mouse femoral artery injury model was subsequently performed. RESULTS: Notoginsenoside R1 attenuated neointimal formation after femoral artery injury in vivo.Notoginsenoside R1 treatment reduced neointimal formation by inhibiting VSMC proliferation. [2]
Synonyms	Sanqi glucoside R1, Sanchinoside R1

Chemical Properties

Molecular Weight	933.13
Formula	C₄₇H₈₀O₁₈
Cas No.	80418-24-2
Smiles	[H][C@@]1(CC[C@]2(C)[C@]1([H])[C@H](O)C[C@]1([H])[C@@]3(C)CC[C@H](O)C(C)(C)[C@]3([H])[C@H](C[C@@]21C)O[C@]1([H])O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O[C@]1([H])OC[C@@H](O)[C@H](O)[C@H]1O)[C@](C)(CCC=C(C)C)O[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O
Relative Density.	1.39 g/cm3 (Predicted)

Storage & Solubility Information

Storage

In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 2.5 mg/mL (2.68 mM), Sonication is recommended.

DMSO: 247.5 mg/mL (265.24 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+90% Saline: 2.5 mg/mL (2.68 mM), Solution.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.0717 mL	5.3583 mL	10.7166 mL	53.5831 mL

DMSO

	1mg	5mg	10mg	50mg
5 mM	0.2143 mL	1.0717 mL	2.1433 mL	10.7166 mL
10 mM	0.1072 mL	0.5358 mL	1.0717 mL	5.3583 mL
20 mM	0.0536 mL	0.2679 mL	0.5358 mL	2.6792 mL
50 mM	0.0214 mL	0.1072 mL	0.2143 mL	1.0717 mL
100 mM	0.0107 mL	0.0536 mL	0.1072 mL	0.5358 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc